@misc{Staszczyk_Małgorzata_Early_2024,
 author={Staszczyk, Małgorzata},
 address={Kraków},
 howpublished={online},
 year={2024},
 school={Rada Dyscypliny Nauki medyczne},
 language={pol; eng},
 abstract={Given the increasing prevalence of early childhood caries (ECC), exploring new preventive methods is justified. This dissertation evaluates the effectiveness of polyols (xylitol, sorbitol, erythritol) and the probiotic Lactobacillus salivarius HM-6 Paradens in inhibiting Streptococcus mutans and reducing caries progression in children. The in vitro study showed that erythritol most effectively inhibited S. mutans biofilm formation, especially on glass ionomer surfaces, while xylitol increased total biomass. The second study, involving 127 children, found that 2- week probiotic supplementation significantly reduced the increase in dentin and cavitated caries (ICDAS 3-6) after 12 months. No effect was observed on early lesions (ICDAS 1-2). However, no reduction in dental plaque was recorded in the probiotic group. Findings suggest that replacing sucrose with erythritol and using glass-ionomers may improve caries prevention and treatment. Probiotics with L. salivarius may support remineralization of existing lesions but not their initiation. Both approaches show promise as adjuncts to current ECC prevention strategies, though further clinical validation is needed.},
 title={Early childhood caries (ECC) : assessment of the usefulness of selected polyols and a probiotic containing Lactobacillus salivarius in inhibiting the growth of Streptococcus mutans and reducing the activity of the caries process},
 type={Praca doktorska},
 keywords={early childhood caries, polyols, probiotics},
}