@misc{Kukułowicz_Jędrzej_Modelowanie_2025,
 author={Kukułowicz, Jędrzej},
 address={Kraków},
 howpublished={online},
 year={2025},
 school={Rada Dyscypliny Nauki farmaceutyczne},
 language={eng},
 abstract={Proteins of the SLC6 family facilitate the transport of small polar molecules across the cell membrane using electrochemical gradient. This family is divided into four subfamilies, namely transporters for monoamine, glycine, GABA, and neutral amino acids. They play critical roles in neurotransmission, nutrition, and homeostasis. Substrates of the neutral amino acid transporters (SLC6A15-SLC6A20) are involved in nutrition and signaling. This thesis involves the structural characterization of SLC6A15 (B°AT2), SLC6A17 (NTT4), and SLC6A20 (SITI). B°AT2, NTT4 and SITI play a role in maintaining neuronal homeostasis in the central nervous system. Their dysfunction is implicated in psychiatric disorders, making them potential therapeutic targets against these disorders. Homology modeling of B°AT2 and NTT4 revealed common residues in the substrate transport pathway of these transporters, explaining a similar substrate preference. Computational studies on B°AT2 inhibition by loratadine allowed to identify tiagabine as a new inhibitor of B°AT2 and SITI. Furthermore, molecular dynamics studies of NTT4 mutants implicated with mental retardation, explained determinants of their dysfunction at the molecular level.},
 title={Modelowanie struktur transporterów dla aminokwasów obojętnych z rodziny SLC6},
 type={Praca doktorska},
 keywords={solute carrier 6, membrane transporters, neutral amino acid transporters},
}