Advanced search ?

Object

Access Limited

This publication is protected and can be accessed only from certain IPs.
This publication is protected and can be accessed only from certain IPs.

Title: The examination of neuropsychotropic properties of some new [gamma]-aminobutyric acid derivatives (GABA)

Author:

Partyka, Anna

Date:

2006

Type:

Praca doktorska

Abstract:

In present study the anticonvulsant-, anxiolytic- and antidepressant-like activity of two groups of γ-aminobutyric acid (GABA) derivatives: 6 amide GABA analogues and 3 phosphinic acid analogues were examined. Results of GABA amide derivatives demonstrate that some of these compounds had anticonvulsant- and/or antidepressant-like activity. None of six investigated GABA amide analogues exihibited the affinity to GABA-ergic receptors, thus their pharmacological effects are not mediated by direct interaction with GABA-ergic neurotransmission. The preliminary screening of three phosphinic acid analogues showed anticonvulsant-like activity of the GABAB receptors agonist (CGP 44532), anxiolytic-like effects of the GABAB receptors antagonist (CGP 36742) and antidepressant-like properties of the GABAB receptors antagonists (CGP 36742, CGP 51176). CGP 44532 antagonizes the antidepressant-like activity of CGP 51176 in the forced swim test in mice, which indicates that this effect is mediated by GABAB receptors. Moreover, chronic treatment with CGP 51176 induced GABAB receptor up-regulation in mouse hippocampus. Obtained data indicate that GABAB receptor antagonism may serve as a basis for the creation of novel antidepressants and support the hypothesis of involvement of GABA-ergic system in the mechanism of antidepressant therapy.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmakologia

Degree grantor:

Wydział Farmaceutyczny

Promoter:

Nowak, Gabriel

Date issued:

2006

Identifier:

oai:dl.cm-uj.krakow.pl:1128

Call number:

ZB-105507

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

GABAB receptors anxiety convulsions depression GABA

Object collections:

Last modified:

Jul 19, 2022

In our library since:

Nov 21, 2012

Number of object content hits:

12

Number of object content views in PDF format

0

All available object's versions:

http://149.156.57.56:8080/publication/1128

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-105507 Jul 19, 2022

Objects

Similar

The examination of neuropsychotropic properties of some new [gamma]-aminobutyric acid derivatives (GABA)

Partyka, Anna

2006
Praca doktorska

The role of GPR39 in the glutamatergic and gabaergic transmission

Starowicz, Gabriela

2020
Praca doktorska

Structure modelling of gamma-aminobutyric acid and glycine transporters as important biological targets

Łątka, Kamil

2023
Praca doktorska

Synthesis of new 2-substituted propionic acid derivatives - GABA and/or monoamines reuptake inhibitors

Gryzło, Beata

2017
Praca doktorska

Pain intensity level vs. emotional status and activity of hospitalised adolescents with cancer

Cepuch, Grażyna

2005
Praca doktorska

Psychotropic activity of long chain azinesulfonamide-arylpiperazine derivatives

Wróbel-Biedrawa, Dagmara

2014
Praca doktorska

Pharmacological activity of novel arylpiperazine alkyl derivatives of salicylamide in the central nervous system

Żmudzka, Elżbieta

2020
Praca doktorska

Selected psychological factors in etiology of preterm birth

Grzyb, Izabella

2016
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information