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Title: Influence of acenocoumarol administration on the development and course of experimental acute pancreatitis

Author:

Sendur, Paweł

Date:

2015

Type:

Praca doktorska

Abstract:

The aim of the study was: (1) to determine the influence of acenocoumarol, a vitamin K antagonist, on the development of experimental acute pancreatitis evoked by primary vascular and non–vascular factor; (2) to evaluate the therapeutic effect of acenocoumarol in the course of acute pancreatitis. Acute pancreatitis was induced in Wistar rats by severe pancreatic ischemia followed by reperfusion (vascular model of acute pancreatitis) or by intraperitoneal administration of cerulein (non-vascular model of acute pancreatitis). The study has shown that: (1) Pretreatment with low doses of acenocoumarol exhibits universal protective effect in the pancreas and inhibits the development of acute pancreatitis evoked by primary vascular and non-vascular factors; (2) Administration of acenocoumarol after induction of acute pancreatitis reduces severity of acute ischemia/reperfusion-induced pancreatitis and accelerates recovery in this disease.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

fizjologia ; choroby układu trawiennego

Degree grantor:

Wydział Lekarski

Promoter:

Warzecha, Zygmunt

Date issued:

2014

Identifier:

oai:dl.cm-uj.krakow.pl:4136

Call number:

ZB-123682

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

acenocoumarol healing acute pancreatitis prevention

Object collections:

Last modified:

Mar 16, 2023

In our library since:

Jan 20, 2017

Number of object content hits:

20

Number of object content views in PDF format

0

All available object's versions:

http://149.156.57.56:8080/publication/4136

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Edition name Date
ZB-123682 Mar 16, 2023

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