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Title: Urinary concentration of biomarkers of occupational exposure to polycyclic aromatic hydrocarbons, and its relationship to chosen genetic mutations

Author:

Zając, Joanna

Date:

2017

Type:

Praca doktorska

Abstract:

The main aim of presented studies was measurement of two biomarkers: 1-hydroxypyrene and 3-hydroxybenzo[a]pyrene, in context of occupational exposition to PAHs. Detailed aims included assessment of: exposition at different work posts, impact of smoking status, connection between biomarkers’ concentration and ambient air monitoring, and, for 1-hydroxypyrene, comparison with occupatio-nally non exposed group to assess exposition level among individuals living near coke plant. Moreover a summary of usefulness of both biomarkers in practice was done. In addition the relationship between benzo[a]pyrene metabolite concentration and chosen mutations in genes (CYP1A1, CYP1B1, GSTM1 and GSTT1) was researched. Study group included individuals occupationally exposed to PAH, control group included individuals living around the coke plant. In the study high performance liquid chromatography and techniques based on PCR were used. Among others, the studies show statistically significant correlation with ambient air monitoring for 1-hydroxypyrene, also statistically significant differences between work posts or influence of smoking status. The dependence between concertation of 3-hyroxy-benzo[a]pyrene and mutations in chosen genes was described. In control group, a relationship between distance of living places from the coke plant and biomarker concentration was not detected.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

biochemia ; medycyna pracy

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Emilia Kolarzyk

Date issued:

2017

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4237

Call number:

ZB-127773

ControlNumberVIRTUA:

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Language:

pol ; eng

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

polycyclic aromatic hydrocarbons biomarkers of occupational exposure 1-hydroxypyrene 3-hydroxybenzo[a]pyrene genetic mutations

Object collections:

Last modified:

Apr 27, 2018

In our library since:

Apr 4, 2018

Number of object content hits:

25

Number of object content views in PDF format

9

All available object's versions:

http://149.156.57.56:8080/publication/4238

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Edition name Date
ZB-127773 Apr 27, 2018

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