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Tytuł: The impact of bariatric and metabolic surgery on premature aging processes in patients with obesity

Autor:

Dudek, Alicja

Data:

2025

Typ:

Praca doktorska

Abstrakt:

Obesity, a growing global health challenge, is associated with the accumulation of low-grade chronic inflammation. The resulting tissue degeneration and development of comorbidities resembłe the processes observed in aging. The aim of this study was to evaluate the impact of obesity and metabolic bariatric surgery on biological aging markers, including telomere length, inflammation, DNA damage, metabolic age, and cognitive function. In a combination of cross-sectional and prospective cohort studies, over 100 patients ąualified for laparoscopic sleeve gastrectomy (LSG) or Roux-en-Y gastric bypass (RYGB) were assessed, alongside healthy control groups. The influence of obesity severity and associated comorbidities on aging markers was analyzed, as well as changes in these markers two years post-surgery. The results showed that obesity is associated with shorter telomeres, higher levels of inflammation, and increased metabolic age. Bariatric surgery significantly improved these parameters- regardless of the clinical weight-loss outcome. These fmdings suggest that surgical treatment may reduce features of premature aging, highlighting its role not only in weight reduction but also in slowing down aging-related biological processes.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

chirurgia ; endokrynologia

Instytucja nadająca tytuł:

Rada Dyscypliny Nauki medyczne

Promotor:

Major, Piotr ; Zapała, Barbara

Data wydania:

2025

Identyfikator:

oai:dl.cm-uj.krakow.pl:6114

Sygnatura:

ZB-143677

Język:

pol; eng

Prawa dostępu:

nieograniczony

Temat i słowa kluczowe:

obesity metabolic syndrome markers of biological age ageing metabolic surgery

Kolekcje, do których przypisany jest obiekt:

Data ostatniej modyfikacji:

9 mar 2026

Data dodania obiektu:

6 mar 2026

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http://149.156.57.56:8080/publication/6115

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Nazwa wydania Data
ZB-143677 9 mar 2026

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Dane kontaktowe

Adres

Biblioteka Medyczna
ul. Medyczna 7
30-688 Kraków

Telefon

12 658 72 56
517 385 669

E-Mail

Oddział Gromadzenia i Opracowania Zbiorów
cyfrowabm@cm-uj.krakow.pl

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