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Title: Evaluation of phototransformation pathways of selected antibiotics in terms of formation of products with potential toxic effects
Abstract:
An analysis of the literature indicates that the presence of antibiotics in the environment can result in complex biotic and abiotic transformations. Of particular importance is phototransformation under the influence of sunlight, which can result in the formation of compounds with increased or decreased toxicity compared to the parent substance. This study aimed to identify phototransformation products of cefuroxime axetil, cefepime, and cefazolin and comprehensively evaluate their toxicity using in silico, in vitro, in vivo, and bioindication methods. The first stage of the study involved exposing the antibiotic solutions to UV-Vis radiation, followed by quantitative analysis using the UPLC-MS/MS method. In silico models were used to determine the potential ecotoxicity of antibiotics and their photodegradation products. To assess the ecological risk, bioindication tests were performed: Thamnotoxkit F using the crustacean Thamnocephalus platyurus and Daphtoxkit F based on Daphnia magna organisms. The multi-species LumiMARA test using 11 strains of naturally luminescent bacteria and the MTT test for cytotoxicity assessment were also used. The final stage was to conduct embryotoxicity tests using Danio rerio embryos. It was shown that the photodegradation of the tested antibiotics leads to the formation of compounds with increased toxicity to model organisms, which emphasizes th ; e need to take drug metabolites into account in environmental risk assessment.
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Rada Dyscypliny Nauki farmaceutyczne
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Last modified:
Apr 14, 2026
In our library since:
Apr 14, 2026
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http://149.156.57.56:8080/publication/6144
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| Edition name | Date |
|---|---|
| ZB-144159 | Apr 14, 2026 |
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