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Title: Monitoring of endothelial function in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors

Author:

Szczepanek, Elżbieta

Date:

2024

Type:

Praca doktorska

Abstract:

We extended knowledge regarding the occurrence of cardiovascular events in patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs) and assessed the function of the vascular endothelium in these patients, particularly in relation to cardiovascular risk factors. Patients with CML who commenced therapy with imatinib in chronic phase achieved long overall survival as well as progression- free and free from late adverse events survival, treatment strategy for ponatinib was presented, takmg mto also in the cardiovascular system. The optimal account the adverse effect of this drug on the function of vascular endothelium. Endothelial function in those patients assessed based on the FMD, FMSF, and RH-PAT tests was mainly related to CML-specific factors, including the duration of TKis treatment and ponatinib rather than to cardiovascular risk based on SCORE2/SCORE2-0P algorithms. FMSF-based assessment of skin microcirculation proved to be a sensitive method for detecting the vascular effects of TKIs.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Sacha, Tomasz

Date issued:

2024

Identifier:

oai:dl.cm-uj.krakow.pl:5188

Call number:

ZB-141640

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

chronic myeloid leukemia tyrosine kinase inhibitors endothelial function cardiovascular risk SCORE2

Object collections:

Last modified:

Jan 28, 2025

In our library since:

Jan 28, 2025

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0

Number of object content views in PDF format

0

All available object's versions:

http://149.156.57.56:8080/publication/5189

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Edition name Date
ZB-141640 Jan 28, 2025

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